Joerg Betschinger is a Group Leader at the Friedrich Miescher Institute for Biomedical Research in Basel.
Cell identity is encoded in self-propagating regulatory networks that confer cell state stability. Most cells, however, acquire their identity during development by transiting through progressively restricted cell states. Thus, destabilization of existing and emergence of prospective regulatory networks underlies cell fate determination, and is reflected in the lineage progression from stem and progenitor cells into mature cell types.
Our research aims at deciphering mechanisms and logics driving cell state transitions using pluripotent stem cells as a paradigm. In particular, by combining genetic and biochemical approaches, we target the identification of modules that regulate cell state changeover, to specify the underlying network dynamics, and to deduce routines conferring network plasticity.
For detail and recent publications: www.fmi.ch/research/groupleader/