Gray Camp is a research group leader at the Institute of Molecular and Clinical Ophthalmology Basel (IOB) in Basel Switzerland, an affiliate institution of the University of Basel, University Hospital Basel, and Novartis. His group uses single-cell genomics and stem cell-derived three-dimensional organoids to understand human development, disease, and evolution. The group is interested in how diverse cells are generated during organ formation, how these cells organize themselves in complex microenvironments, and how this process can fail during genetic and other disorders. They work with multiple organ-organoid systems including the brain, retina, and gut in order to identify developmental mechanisms that are common and specific to each tissue. At the IOB, the group is using isogenic and patient-derived stem cell lines to recapitulate retinal malformations in controlled culture environments, and using single-cell genomics and imaging to understand the disease mechanisms. A major goal in the group is to generate accurate and personalized models of retina developmental disorders, and assist with the development of novel corrective therapies. The Camp lab is also fascinated by the evolutionary path that our cells took to become uniquely human, and they are using organoids to explore how human cells are different from our closest living relatives, chimpanzees and the other great apes.
For detail and recent publications: iob.ch/research/molecular-research-center/group-gray-camp/