Radek Skoda is Professor of Molecular Medicine in the Department of Biomedicine of the University of Basel and the University Hospital Basel. His research group "Experimental Hematology" studies the molecular pathogenesis of myeloproliferative neoplasms (MPN) that represent clonal stem cell disorders with a tendency towards leukemic transformation. MPN are characterized by aberrant proliferation of precursors of the myeloid, erythroid and megakaryocytic lineages resulting in elevated blood counts for red cell, platelet and neutrophil granulocytes. Oncogenic driver mutations in the genes for Janus kinase 2 (JAK2), Calreticulin (CALR) or the thrombopoietin receptor (MPL) can be found in >90% of MPN patients, but additional mutations in genes encoding epigenetic regulators or signaling proteins are detectable in some of the patients. His group uses blood samples from MPN patients and mouse models of MPN to investigate how these mutations alter stem cell properties and interact in disease initiation and progression. This work involves functional and molecular analyses of single hematopoietic stem cells.Radek Skoda is the principal investigator of the StemSysMed project supported by SystemX. His group has collaborations with groups in Basel as well as with the group of Markus Manz in Zurich and Simon Mendez-Ferrer in Madrid.
For detail and recent publications: https://biomedizin.unibas.ch/en/persons/radek-c-skoda/