How neuromuscular connections are maintained after nerve lesions
After nerve injury, the protein complex mTORC1 takes over an important function in skeletal muscle to maintain the neuromuscular junction, the synapse between the nerve and muscle fiber. The team led by Prof. Markus Rüegg at the Biozentrum of the University of Basel has now shown that the activation of mTORC1 must be tightly balanced for a proper response of the muscle to nerve injury. The study published in «Nature Communications» opens new insights into muscle weakness related to neuromuscular diseases or caused by ageing.
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