Dirk Schübeler is the Director of the Friedrich Miescher Institute for Biomedical Research in Basel and the Senior Group Leader. His group studies the role of epigenetic modifications of DNA and nucleosomes in transcriptional regulation and genome maintenance. A particular interest is the role of epigenetic regulation in stabilizing transcriptional programs in defined cellular states and how it relates to the developmental potential of a given cell. The regulation of pluripotency of stem cells and their epigenetic reprogramming during differentiation provide important models to address these questions. To understand how stem cell maintenance and loss of pluripotency are regulated via chromatin and DNA methylation the group develops and applies functional genomics approaches. With these quantitative measures of the epigenome are performed to identify regulatory patterns and their function in cell fate decisions.

Dirk Schübeler is an elected member of the European Network of Excellence “The epigenome”, an EMBO Young Investigator and member of the Swiss Systems Biology initiative on Cell Plasticity.

For detail and recent publications: https://www.fmi.ch/research/groupleader/?group=34