Barbara Treutlein is an Associate Professor at the Department of Biosystems Science and Engineering of ETH Zürich in Basel. Her group uses and develops quantitative single-cell genomic approaches to understand the mechanisms underlying development, regeneration and reprogramming. In particular, they use stem cell derived human organoids to model the development of human organs in vitro and to understand how cell fate is orchestrated in complex human tissues. In recent years, her group have shown that cell composition, lineage relationships and gene networks controlling human cerebral and liver organoid development are remarkably similar to those in the developing human fetus. They are now manipulating these stem cell derived tissues and growing tissues from human patients with developmental disorders to find out how certain genes and gene networks contribute to the establishment of different cell lineages. They are also analyzing the cellular dynamics of early organoid development to identify when and where patterning emerges and lineages diverge. Further, the group has been using single-cell transcriptomics to understand mechanisms underlying the direct reprogramming of fibroblasts and pericytes into induced neuronal cells. Finally, the Treutlein group has been collaborating with Elly Tanaka’s lab to provide a molecular view of individual cells as they are regenerating an axolotl limb.

For detail and recent publications: https://bsse.ethz.ch/department/people/detail-person.MjUwODcx.TGlzdC8yNjY5LDEwNjI4NTM0MDk=.html